No particular dose adjustment advisable when tofacitinib coadministered with powerful CYP2C19 inhibitors; reduce tofacitinib dose if coadministered with both of those average CYP3A4 and powerful CYP2C19 inhibitors .Hepatic impairment: In people with significant hepatic impairment, modafinil dose ought to be minimized by a single-half of the usual
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